Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.
 

We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

Key Sessions

• Keynote and Emerging Topics
• Novel models and technologies to study pulmonary fibrosis
• Mechanisms of repair in lung disease
• Pathways regulating Lung Development and dysregulated/activated in lung fibrosis
• Aging, Fibrosis and degenerative lung diseases
• Environmental impact on lung diseases
• Mechanotransduction In Lung Development and Fibrosis
• Aging and Lung Fibrosis

Confirmed Keynote Speaker

Mark Krasnow (Stanford University)

Confirmed Invited Speakers

Denise Al Alam (The Lundquist Institute)
Douglas Brownfield (Mayo Clinic)
Oliver Eickelberg (University of Pittsburgh)
John Engelhardt (University of Iowa)
ASSESSING LUNG INJURY AND REPAIR USING TRANSGENIC FERRET MODELS
Andreas Günther (University of Giessen)
Claudia Jackubzick (Dartmouth College)
BIOLOGY OF LUNG MACROPHAGES IN HEALTH AND DISEASE
Vladimir Kalinichenko (University of Arizona College of Medicine, Phoenix)
DEVELOPING NEW THERAPEUTIC APPROACHES FOR PERINATAL LUNG DISEASES
Naftali Kaminski (Yale School of Medicine)
STEM CELL FAILURE AND ALVEOLAR PLASTICITY IN HUMAN PULMONARY FIBROSIS
Harry Karmouty-Quintana (UT Health Houston)
SINE OCULIS HOMEOBOX 1 (SIX1) A NOVEL PRO-FIBROTIC MEDIATOR
David Lagares (Harvard University)
Joo-hyeon Lee (University of Cambridge)
Claude Jourdan Le Saux (University of California San Francisco)
SECRETED FRIZZLED RELATED PROTEIN 2 CONTRIBUTES TO THE TRANSDIFFERENTIATION OF HUMAN ALVEOLAR EPITHELIAL TYPE II CELLS
Mitsuru Morimoto (RIKEN)
AUTOCRINE TGF-β-POSITIVE FEEDBACK IN PROFIBROTIC AT2-LINEAGE CELLS PLAYS A CRUCIAL ROLE IN NON-INFLAMMATORY LUNG FIBROGENESIS
Enid Neptune (Johns Hopkins University)
EXPLORING THE INTERFACE OF GENETIC DISORDERS AND COPD-EMPHYSEMA
Marko Nikolic (University College London)
HUMAN LUNG AND IMMUNE DEVELOPMENT IN HEALTH AND DISEASE
Jayaraj Rajagopal (Massachusetts General Hospital)
Elizabeth Redente (National Jewish Health)
REDUCING FIBROBLAST PERSISTENCE IN PULMONARY FIBROSIS AS A MECHANISM OF RESOLUTION
Laila Roudsari (United Therapeutics)
FROM CELLS TO ORGAN: THE BUILDING BLOCKS FOR GENERATING FUNCTIONAL LUNG TISSUE
Herbert Schiller (Helmholtz Munich)
Jennifer Sucre (Vanderbilt University)
Xin Sun (UC San Diego)
Aleksandra Tata (Duke University)
Matthew James Thomas (Boehringer Ingelheim)
IN VITRO MODELS OF EPITHELIUM IN PULMONARY FIBROSIS
Andrew Vaughan (University of Pennsylvania)
REGENERATION AND INFLAMMATION IN VIRAL PNEUMONIA: A BALANCING ACT
Ana Ivonne Vazquez-Armendariz (University of Bonn)
Rachel Zemans (Michigan Medicine)
TRANSITIONAL STATES IN LUNG REGENERATION AND FIBROSIS

Target Audience 

• Lung developmental biologists
• Stem cell researchers
• Fibrosis researchers
• Pulmonary fibrosis researchers

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